ChemicalBook CAS DataBase List (3S,4R)-4-(4-Fluorophenyl)-3-[[3-methoxy-4-(phenylmethoxy)phenoxy]methyl]piperidine

(3S,4R)-4-(4-Fluorophenyl)-3-[[3-methoxy-4-(phenylmethoxy)phenoxy]methyl]piperidine synthesis

5synthesis methods

Product Name:(3S,4R)-4-(4-Fluorophenyl)-3-[[3-methoxy-4-(phenylmethoxy)phenoxy]methyl]piperidine
CAS Number:600135-89-5
Molecular formula:C26H28FNO3
Molecular Weight:421.5

1-Piperidinecarboxylic acid, 4-(4-fluorophenyl)-3-[[3-methoxy-4-(phenylmethoxy)phenoxy]methyl]-, ethenyl ester, (3S,4R)-

600135-86-2
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(3S,4R)-4-(4-Fluorophenyl)-3-[[3-methoxy-4-(phenylmethoxy)phenoxy]methyl]piperidine

600135-89-5
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Yield:600135-89-5 87%

Reaction Conditions:

Stage #1: (3S,4R)-4-(4-fluorophenyl)-3-(3-methoxy-4-benzyloxyphenoxymethyl)-1-vinyloxycarbonylpiperidinewith hydrogenchloride in 1,2-dichloro-ethane; for 0.75 h;
Stage #2: with ethanol for 1.5 h;Heating;

References:

Segura, Mireia;Roura, Lidia;De La Torre, Rafael;Joglar, Jesus [Bioorganic Chemistry,2003,vol. 31,# 3,p. 248 - 258]

40232-88-0 Synthesis