3-(2,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER synthesis
- Product Name:3-(2,4-DIMETHOXY-PHENYL)-3-OXO-PROPIONIC ACID ETHYL ESTER
- CAS Number:60946-77-2
- Molecular formula:C13H16O5
- Molecular Weight:252.26
39828-35-8
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6148-64-7
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60946-77-2
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$146.66/0.25g
Yield:60946-77-2 90%
Reaction Conditions:
with triethylamine;magnesium chloride in acetonitrile at 20;
Steps:
1
Experimental operation: Take malonate potassium salt 1.00g (about 5.47mmol) and anhydrous magnesium chloride was added 0.65g (about 6.84mmol) in 25mL round bottom flask, 0.55g triethylamine was dropped after 6mL dissolved in acetonitrile, stirred at room temperature for 30min. Then dropped by 2mL acetonitrile dissolved 0.48g (2.5mmol) 2,4- dimethoxybenzoyl chloride, supplemented triethylamine 0.06mL, stirred at room temperature overnight. Post-treatment: 30mL of water was added to dilute the reaction solution, and then were added 30,20,20mL ethyl acetate, and the ethyl acetate layer was collected. After washing with saturated brine 30mL ethyl acetate layer was dried over anhydrous sodium sulfate, and spin dry column chromatography (PE: EA = 15: 1) to give the product isolated 2a, a yield of 90%
References:
CN105566340,2016,A Location in patent:Paragraph 0010
829-20-9
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105-58-8
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60946-77-2
25 suppliers
$146.66/0.25g