3-Hydroxy-6-Methyl-2-pyridinecarboxylic acid Methyl ester synthesis
- Product Name:3-Hydroxy-6-Methyl-2-pyridinecarboxylic acid Methyl ester
- CAS Number:61548-52-5
- Molecular formula:C8H9NO3
- Molecular Weight:167.16
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61548-52-5
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Yield:61548-52-5 100%
Reaction Conditions:
with triethylamine;bis-triphenylphosphine-palladium(II) chloride at 100; under 7500.75 Torr; for 3 h;
Steps:
2-Iodo-6-methylpyridin-3-ol (0.402 g), bis(triphenylphosphine)palladium(II) chloride (1.2 g) and NEt3 (0.262 mL) in MeOH (50 mL) were stirred under an atmosphere of carbon monoxide at 10 bar and 100° C. for 3 h. The mixture was then filtered and concentrated in vacuo to afford the title compound (0.286, 100%)
References:
US2009/48269,2009,A1 Location in patent:Page/Page column 64
67-56-1
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61548-52-5
42 suppliers
$64.00/100mg