methyl (E)-4-(3-(tert-butoxy)-3-oxoprop-1-en-1-yl)benzoate synthesis
- Product Name:methyl (E)-4-(3-(tert-butoxy)-3-oxoprop-1-en-1-yl)benzoate
- CAS Number:683246-09-5
- Molecular formula:C15H18O4
- Molecular Weight:262.3
Yield:683246-09-5 100%
Reaction Conditions:
with C36H36Cl2N6Pd;triethylamine in methanol at 70; for 24 h;Heck Reaction;
Steps:
General procedure for the Heck reaction
General procedure: The reaction vessel was charged with halobenzene (5 mmol), triethylamine (10 mmol), t-butyl acrylate (6.25 mmol) and a catalyst (0.5 mol%) in MeOH (10 ml). The reaction mixture was heated and refluxed in a pre-heated oil bath (70 °C) for 24 h. At the end of the reaction, the reaction mixture was diluted with n-hexane and washed with water. The combined organic portion was dried over anhydrous MgSO4. After removal of the solvent, the desired product was purified by column chromatography using ethyl acetate andhexane mixtures to obtain the Heck product.
References:
Chou, Chang-Chuan;Yang, Chia-Chi;Syu, Hong-Bin;Kuo, Ting-Shen [Journal of Organometallic Chemistry,2013,vol. 745-746,p. 387 - 392]
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