(6R)-6-methylmorpholin-3-one synthesis
- Product Name:(6R)-6-methylmorpholin-3-one
- CAS Number:127958-66-1
- Molecular formula:C5H9NO2
- Molecular Weight:115.13
2799-16-8
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127958-66-1
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Yield:127958-66-1 5.3%
Reaction Conditions:
Stage #1: (2R)-hydroxypropylaminewith sodium hydride in N,N-dimethyl-formamide;mineral oil at 0 - 20; for 0.666667 h;Inert atmosphere;
Stage #2: chloroacetic acid ethyl ester in N,N-dimethyl-formamide;mineral oil at 100; for 16 h;Inert atmosphere;
References:
Haftchenary, Sina;Nelson, Shawn D.;Furst, Laura;Dandapani, Sivaraman;Ferrara, Steven J.;Bo?kovi?, ?arko V.;Figueroa Lazú, Samuel;Guerrero, Adrian M.;Serrano, Juan C.;Crews, Demarcus K.;Brackeen, Cristina;Mowat, Jeffrey;Brumby, Thomas;Bauser, Marcus;Schreiber, Stuart L.;Phillips, Andrew J. [ACS Combinatorial Science,2016,vol. 18,# 9,p. 569 - 574] Location in patent:supporting information