7-Aza-spiro[3.5]nonane synthesis
- Product Name:7-Aza-spiro[3.5]nonane
- CAS Number:766-34-7
- Molecular formula:C8H15N
- Molecular Weight:125.21
![tert-butyl 2-oxo-7-azaspiro[3.5]nonane-7-carboxylate](/CAS/GIF/203661-69-2.gif)
203661-69-2
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$8.00/250mg
766-34-7
37 suppliers
$156.00/50mg
Yield:766-34-7 93%
Reaction Conditions:
with hydrazine hydrate;sodium hydroxide at 200; for 4 h;Reflux;
Steps:
12.3 7-azaspiro[3.5]nonane
The 20-3 (5.6g, 23.4mmol), hydrazine hydrate (8.10g, 161.8mmol) and NaOH (5.85g, 146.4mmol) was dissolved in three polyethylene glycol (100mL), was heated under reflux for 1 hour.Condenser is then removed, and the temperature was heated to 200 deg.] C for 3 hours.After cooling, water was added and 100mL of diethyl ether mixture, liquid separation, extraction, the organic phase was dried and concentrated by silica gel column chromatography to give 20-4 (2.8 g, 93%).
References:
CN103635456,2016,B Location in patent:Paragraph 0387-0389
159635-49-1
7 suppliers
$5.00/250mg
766-34-7
37 suppliers
$156.00/50mg
![tert-butyl 1,1-dichloro-2-oxo-7-azaspiro[3.5]nonane-7-carboxylate](/CAS/20180601/GIF/396653-31-9.gif)
396653-31-9
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766-34-7
37 suppliers
$156.00/50mg