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ChemicalBook CAS DataBase List 7-Benzothiazolecarboxylicacid,Methylester

7-Benzothiazolecarboxylicacid,Methylester synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1.1: sulfuric acid / chlorobenzene / -10 °C
1.2: -10 - 100 °C
2.1: bromine; acetic acid / 0 - 70 °C
3.1: isopentyl nitrite / tetrahydrofuran / 4 h / Reflux

References:

ACTELION PHARMACEUTICALS LTD WO2009/104155, 2009, A1