7-Bromothieno[3,2-d]pyrimidin-2-amine synthesis

6synthesis methods

Product Name:7-Bromothieno[3,2-d]pyrimidin-2-amine
CAS Number:1293987-58-2
Molecular formula:C6H4BrN3S
Molecular Weight:230.09

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Yield:1293987-58-2 60%

Reaction Conditions:

with ammonia in isopropyl alcohol at 100; for 48 h;Sealed reactor;

Steps:

19.1

7-Bromo-2-chlorothieno[3,2-d]pyrimidine (1.0 g, 4.03 mmol) was dissolved in 2.0 M ammonia isopropanol (10 mL) and stirred at 100 °C for 48 hours in a sealed reactor. The reaction mixture was cooled to room temperature and then concentrated. Purification by chromatography (50% ethyl acetate/hexane) yielded a brown solid compound (560 mg, 60% yield). [0253] ¹H NMR (400 MHz, DMSO-d ₆) δ 8.95 (s, 1H), 8.36 (s, 1H), 6.89 (s, 2H), MS m/z: 230.26, 232.26 [M+1].

References:

WO2011/49332,2011,A2 Location in patent:Page/Page column 29