7-chloro-Thieno[3,2-b]pyridine-2-carboxaldehyde synthesis
- Product Name:7-chloro-Thieno[3,2-b]pyridine-2-carboxaldehyde
- CAS Number:387819-41-2
- Molecular formula:C8H4ClNOS
- Molecular Weight:197.64
![7-Chlorothieno[3,2-b]pyridine](/CAS/GIF/69627-03-8.gif)
69627-03-8
171 suppliers
$6.00/100mg
387819-41-2
30 suppliers
$265.00/2.5g
Yield:387819-41-2 73%
Reaction Conditions:
with n-butyllithium in tetrahydrofuran at -78; for 3 h;Inert atmosphere;
Steps:
81
Dissolve compound E70 (5.08g, 30mmol) in anhydrous tetrahydrofuran (50mL), fill it with argon protection, slowly add n-butyllithium (15.6mL, 39mmol) dropwise at -78°C, keep -78°C and stir for 1h, slowly Anhydrous N',N-dimethylformamide (7.63mL, 99mmol) was added dropwise, kept at -78°C and stirred for 2h, then naturally warmed to room temperature, stirred overnight, 1M hydrochloric acid (130mL) was added, and the precipitated solid was filtered with suction. Infrared drying gave E71 a white solid (4.32 g, yield 73%).
References:
CN112608320,2021,A Location in patent:Paragraph 0604-0606
107818-20-2
156 suppliers
$10.00/250mg
387819-41-2
30 suppliers
$265.00/2.5g