7-FLUORO INDAZOLE synthesis
- Product Name:7-FLUORO INDAZOLE
- CAS Number:341-24-2
- Molecular formula:C7H5FN2
- Molecular Weight:136.13
18355-80-1
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$10.00/1g
341-24-2
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$10.00/1g
Yield: 41%
Reaction Conditions:
with hydrazine hydrateReflux;
Steps:
4.1.1. General procedure for the synthesis of fluoro-1H-indazoles 2c, 2d
General procedure: The title compounds were obtained by modifying a method described by Lukin et al. [63]. To the properly substituted 2-fluorobenzaldehyde (5 g, 35 mmol) was added hydrazine hydrate (12.9 g, 258 mmol, 12.5 ml). After stirring for 12-48 h (TLC control) at reflux water (20 ml) was added and the resulting mixture was cooled to 5 °C. The precipitate was collected by vacuum filtration. The filtrate was extracted with dichloromethane and the residue after evaporation was combined with the precipitate.
References:
Wasilewska, Aleksandra;Sączewski, Franciszek;Hudson, Alan L.;Ferdousi, Mehnaz;Scheinin, Mika;Laurila, Jonne M.;Rybczyńska, Apolonia;Boblewski, Konrad;Lehmann, Artur [European Journal of Medicinal Chemistry,2014,vol. 87,p. 386 - 397]
2646-91-5
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$5.00/250mg
341-24-2
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$10.00/1g
394-50-3
229 suppliers
$9.00/250mg
341-24-2
116 suppliers
$10.00/1g