Ethyl4-oxo-7-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylate synthesis
- Product Name:Ethyl4-oxo-7-(trifluoromethyl)-1,4-dihydroquinoline-3-carboxylate
- CAS Number:71083-04-0
- Molecular formula:C13H10F3NO3
- Molecular Weight:285.22
![diethyl [(alpha,alpha,alpha-trifluoro-m-toluidino)methylene]malonate](/CAS/GIF/370-35-4.gif)
370-35-4
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71083-04-0
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Yield:71083-04-0 89%
Reaction Conditions:
in diphenylether at 235; for 1 h;Inert atmosphere;
Steps:
5.1.3. General procedure B: Synthesis of compounds 12 a-d
General procedure: The malonate derivates 11a-d were dispersed in diphenylether(1.7 mL/mmol), flushed with argon and heated to 235 °C for 1 h with aheating jacket. The reaction mixture was poured into petroleum ether,the formed precipitate was collected by filtration and washed with amixture of LP/EtOAc 1/1 to yield the desired product.
References:
Simeone;Iorio;Siebert;Rehman;Schnürch;Mihovilovic;Ernst [Bioorganic and Medicinal Chemistry,2019,vol. 27,# 14,p. 3167 - 3178] Location in patent:supporting information
98-16-8
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71083-04-0
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$75.00/500mg
87-13-8
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71083-04-0
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370-35-4
7 suppliers
$28.60/250mg
71083-04-0
21 suppliers
$75.00/500mg
56881-18-6
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105-53-3
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71083-04-0
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$75.00/500mg