2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine synthesis
- Product Name:2,6-Dichloro-4,8-dipiperidinopyrimidino[5,4-d]pyrimidine
- CAS Number:7139-02-8
- Molecular formula:C16H20Cl2N6
- Molecular Weight:367.28
110-89-4
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![2,4,6,8-TETRACHLOROPYRIMIDO[5,4-D]PYRIMIDINE](/CAS/GIF/32980-71-5.gif)
32980-71-5
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7139-02-8
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Yield:7139-02-8 95%
Reaction Conditions:
with copper(l) iodide;caesium carbonate in nitrobenzene at 180; for 16 h;Inert atmosphere;
Steps:
4.g Example 4: Synthesis of perchloropyrimido [5,4-d] pyrimidine
the entire chlorine pyrimido [5, 4 - d] pyrimidine (13.1 g, 48.9 mmol), piperidine, CuI (0.28 g, 1.5 mmol), Cs2 CO3 (16.0 g, 48.9 mmol) is put into the 250 in two mouth flask, add 100 ml nitrobenzene as the reaction solvent, under the protection of nitrogen, 180 °C lower reaction 16 h, oil pump by reducing pressure after the reaction of the nitrobenzene solvent, PE:DCM=6:1 to column chromatography, obtaining the solid 17.0 g, yield of 95.0%, the selectivity 99%
References:
CN106946887,2017,A Location in patent:Paragraph 0035; 0036; 0037
6713-54-8
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7139-02-8
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7139-02-8
121 suppliers
$6.00/250mg