N-(4-CHLOROPHENYL)-N'-[(DIMETHYLAMINO)METHYLENE]THIOUREA synthesis

Yield:73161-60-1 73%

Reaction Conditions:

in methanol at 20;

Steps:

4.3.2.3. Synthesis and characterization of substituted N'-carbamothioyl-N,N-dimethylformimidamide (6a-e)

General procedure: 4.3.2.3.1. N'-carbamothioyl-N,N-dimethylformimidamide(6a). Thiourea 5a (1.0 eq) in methanol was reacted with 1,1-dimethoxy-N,N-dimethylmethanamine (2.0 eq) at room temperature for 3 h to get N'-carbamothioyl-N,N-dimethylformimidamide 6a. After completion of reaction, methanol was evaporated in vacuo to get compound 6a. 6a was used without further purification.

References:

Sagar, Sneha R.;Singh, Devendra Pratap;Das, Rajesh D.;Panchal, Nirupa B.;Sudarsanam, Vasudevan;Nivsarkar, Manish;Vasu, Kamala K. [Bioorganic Chemistry,2019,vol. 89,art. no. 102992]