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N,N-Dimethylformamide dimethyl acetal

N,N-Dimethylformamide dimethyl acetal Structure
N,N-Dimethylformamide dimethyl acetal structure
CAS No.
4637-24-5
Chemical Name:
N,N-Dimethylformamide dimethyl acetal
Synonyms
DMF-DMA;1,1-dimethoxy-n,n-dimethyl-methanamin;DMF-DIMETHYLACETAL;1,1-DIMETHOXYTRIMETHYLAMINE;(Dimethylamino)dimethoxymethane;DIMETHYLFORMAMIDEDIMETHYLACETAL;N-(Dimethoxymethyl)dimethylamine;Dimethoxy-N,N-dimethylmethanamine;N,N-Dimethylformamide dimethyl acetal, 95% (1,1-Dimethoxytrimethylamine);METHYL-8
CBNumber:
CB8178244
Molecular Formula:
C5H13NO2
Molecular Weight:
119.16
MDL Number:
MFCD00008482
MOL File:
4637-24-5.mol
MSDS File:
SDS
Last updated:2025-07-24 18:13:47
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N,N-Dimethylformamide dimethyl acetal Properties

Melting point -85°C
Boiling point 102-103 °C/720 mmHg (lit.)
Density 0.897 g/mL at 25 °C (lit.)
vapor pressure 34.5hPa at 20℃
refractive index n20/D 1.396(lit.)
Flash point 45 °F
storage temp. Store below +30°C.
solubility Miscible with most organic solvents.
form Solid
pka 5.00±0.50(Predicted)
color White to off-white
PH 7 (H2O)
explosive limit 1.3-17.7%(V)
Water Solubility hydrolysis
Sensitive Moisture Sensitive
BRN 506020
Exposure limits ACGIH: TWA 200 ppm; STEL 250 ppm (Skin)
OSHA: TWA 200 ppm(260 mg/m3)
NIOSH: IDLH 6000 ppm; TWA 200 ppm(260 mg/m3); STEL 250 ppm(325 mg/m3)
LogP 0.750 (est)
CAS DataBase Reference 4637-24-5(CAS DataBase Reference)
FDA UNII DF7CTT5QPH
NIST Chemistry Reference Methanamine, 1,1-dimethoxy-N,N-dimethyl-(4637-24-5)
EPA Substance Registry System Methanamine, 1,1-dimethoxy-N,N-dimethyl- (4637-24-5)
UNSPSC Code 12352302
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS05,GHS07
Signal word  Danger
Hazard statements  H225-H317-H318-H332
Precautionary statements  P210-P280-P302+P352-P304+P340+P312-P305+P351+P338+P310
Hazard Codes  F,Xn,Xi
Risk Statements  11-22-36/37/38-36/38-20-20/21/22-10-52
Safety Statements  16-26-36/37-36/37/39-33-29-7/9
RIDADR  UN 3271 3/PG 2
WGK Germany  1
F  21
Autoignition Temperature 155 °C
TSCA  Yes
HazardClass  3
PackingGroup  II
HS Code  29225000
Toxicity LD50 orally in Rabbit: > 5000 mg/kg
NFPA 704
3
3 1

N,N-Dimethylformamide dimethyl acetal price More Price(56)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.03068 N,N-Dimethylformamide dimethyl acetal for synthesis 4637-24-5 25mL $56.8 2025-07-31 Buy
Sigma-Aldrich 140732 N,N-Dimethylformamide dimethyl acetal technical grade, 94% 4637-24-5 25ml $57.76 2025-07-31 Buy
Sigma-Aldrich 140732 N,N-Dimethylformamide dimethyl acetal technical grade, 94% 4637-24-5 2.5l $1340 2025-07-31 Buy
Sigma-Aldrich 8.03068 N,N-Dimethylformamide dimethyl acetal for synthesis 4637-24-5 1mL $34.2 2024-03-01 Buy
Sigma-Aldrich 8.03068 N,N-Dimethylformamide dimethyl acetal for synthesis 4637-24-5 100mL $163 2024-03-01 Buy
Product number Packaging Price Buy
8.03068 25mL $56.8 Buy
140732 25ml $57.76 Buy
140732 2.5l $1340 Buy
8.03068 1mL $34.2 Buy
8.03068 100mL $163 Buy

N,N-Dimethylformamide dimethyl acetal Chemical Properties,Uses,Production

Chemical Properties

clear colourless liquid

Uses

Used to catalyze the coupling of epoxides with carbon dioxide under solvent free conditions leading to cyclic carbonates.

Uses

N,N-Dimethylformamide dimethyl acetal is used as an intermediate in the formation of pyridine derivatives, which exhibits inhibition against PI3 kinase p110alfa enzymes. It is utilized for the derivatization of primary sulfonamides and trifluoroacetic acid. It is also used in the preparation of formamidine derivatives. It is used as a reagent for n-dimethylaminomethylene and methyl esters. Further, it is used to catalyze the coupling of epoxides with carbon dioxide to prepare cyclic carbonates.

Uses

1,1-Dimethoxy-N,N-dimethylmethanamine is used as a reagent in the formation of pyridine derivatives that exhibit inhibition against PI3 kinase p110α enzymes.

Definition

ChEBI: An acetal obtained by formal condensation of N,N-dimethylformamide with methanol. N,N-dimethylformamide dimethyl acetal is a derivatisation agent used in gas-chromatography applica ions

General Description

Esterate M (N,N-Dimethylformamide dimethyl acetal, DMFDMA) is an methylating reagent. It has been used in methyl esterification of carboxylic acid and also in one-step derivatization of amino acids into N,N-Dimethylaminomethylene methyl esters.

Flammability and Explosibility

Highly flammable

reaction suitability

reagent type: derivatization reagent
reaction type: Acylations
reagent type: derivatization reagent
reaction type: Esterifications

Synthesis

Sodium Methoxide

124-41-4

N,N-Dimethylformamide

68-12-2

N,N-Dimethylformamide dimethyl acetal

4637-24-5

A method for synthesizing N,N-dimethylformamide dimethyl acetal, comprising the steps of (1) heating N,N-dimethylformamide to 70°C, mixing with dimethyl sulfate in a molar ratio of 1:1 and reacting for 4 hours after the end of dropwise addition to obtain the imine complex, and then cooling to room temperature; (2) adding solid sodium methanol to 200 solvent oil, dispersing it by ultrasonication, adjusting the temperature to 25 ℃ and maintained, dropwise addition of the imine complex, the reaction for 2 hours and then filtered, the filtrate often pressure fractionation, collection of 105-108 ℃ fraction, to obtain N,N-dimethylformamide dimethyl acetal, the yield was 75.3%, purity of 97%; wherein the molar ratio of sodium methanol to the imine complex is 1:1. The synthesis of the N,N-dimethylformamide dimethyl acetal of Example 6 is the same as that of Example 2, the The difference is that the organic solvent of this embodiment is a mixed solvent oil: D40 solvent oil, D60 solvent oil and 260 solvent oil, with a volume ratio of 2:1:1, to obtain N,N-dimethylformamide dimethyl acetal with a yield of 85.4% and a purity of 97%.

References

[1] Patent: CN106083611, 2016, A. Location in patent: Paragraph 0034-0037; 0048-0049

N,N-Dimethylformamide dimethyl acetal synthesis

124-40-3
149-73-5
4637-24-5
Synthesis of N,N-Dimethylformamide dimethyl acetal from Dimethylamine and Trimethoxymethane

N,N-Dimethylformamide dimethyl acetal Preparation Products And Raw materials

Raw materials

MethanaMiniuM, MethoxydiMethyl-, Methyl sulfate (1:1) Sodium Methoxide N,N-Dimethylformamide

Preparation Products

(5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANAMINE (1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL)METHANOL 1-(3-Pyridyl)-3-(dimethylamino)-2-propen-1-one 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID (5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)METHANOL
1-PHENYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 1-TERT-BUTYL 6-METHYL 3-FORMYL-1H-INDOLE-1,6-DICARBOXYLATE ETHYL 1-(4-FLUOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLATE 3-BROMOCHROMONE 5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-4-CARBONITRILE
5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBONYL CHLORIDE METHYL 4-AMINO-6-INDOLECARBOXYLATE Indole-6-carboxaldehyde ETHYL 1-(TERT-BUTYL)-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLATE 1-PHENYL-5-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBONYL CHLORIDE
(1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-YL)METHANAMINE ETHYL 2-METHYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE 7-Hydroxyindole 6-HYDROXYMETHYLINDOLE ETHYL 2-PHENYL-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE
5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-AMINE (5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOL-4-YL)METHANAMINE 3-NITROBENZO[B]FURAN-5-OL ETHYL 5-METHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLATE 5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBONITRILE
3-NITROISONICOTINALDEHYDE (5-METHYL-1-PHENYL-1H-PYRAZOL-4-YL)METHANOL 2-AMINO-4-METHYL-PYRIMIDINE-5-CARBOXYLIC ACID [1-(4-FLUOROPHENYL)-5-METHYL-1H-PYRAZOL-4-YL]METHANOL 1-METHYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOL-4-AMINE (5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOL-4-YL)METHANOL 4-(Pyridin-3-yl)pyrimidin-2-amine 1-TERT-BUTYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBONITRILE Indole-7-carboxaldehyde
4-Aminomethyl-1-methylpyrazole 5-Hydroxyindole Indole-6-carboxylic acid 5-(TRIFLUOROMETHYL)-1-PHENYL-1H-PYRAZOLE-4-CARBOXAMIDE 5-(TRIFLUOROMETHYL)-1-METHYL-1H-PYRAZOLE-4-CARBOXAMIDE

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N,N-Dimethylformamide dimethyl acetal Suppliers

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Changzhou Xuanming Pharmaceutical Technology Co., Ltd. 		+86-519-85525359 +86-15995072465 sales@xuanmingchem.com China 892 58
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+8613401983379 sales@njmcn.cn CHINA 74 58
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027-88013699 17354350817 Ryan@jiutian-bio.com China 5944 58
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Changzhou Xuanming Pharmaceutical Technology Co., Ltd. 		58
Nanjing Sinoda Biological Technology Co., Ltd
58
Hu Bei Jiutian Bio-medical Technology CO.,Ltd
58
Hebei Chuanghai Biotechnology Co., Ltd 		58
Nanjing Hike Biological Technology CO. Ltd. 		58
Hebei Chuanghai Biotechnology Co,.LTD 		58
Shaanxi Didu New Materials Co. Ltd 		58
Capot Chemical Co.,Ltd. 		60
Shanghai Daken Advanced Materials Co.,Ltd 		58
Hi-Tech Chemistry Corp 		58

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View Lastest Price from N,N-Dimethylformamide dimethyl acetal manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
N,N-Dimethylformamide dimethyl acetal pictures 2025-08-11 N,N-Dimethylformamide dimethyl acetal
4637-24-5
 0.99 RongNa Biotechnology Co.,Ltd
N,N-Dimethylformamide dimethyl acetal pictures 2025-08-08 N,N-Dimethylformamide dimethyl acetal
4637-24-5
 US $100.00 / KG 1KG 99% 5000kg/week Hebei Mujin Biotechnology Co.,Ltd
N,N-Dimethylformamide dimethyl acetal pictures 2025-07-25 N,N-Dimethylformamide dimethyl acetal
4637-24-5
 US $0.00-0.00 / KG 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd

N,N-Dimethylformamide dimethyl acetal Spectrum

N,N-Dimethylformamide dimethyl acetal(4637-24-5)1HNMRN,N-Dimethylformamide dimethyl acetal(4637-24-5)IR1N,N-Dimethylformamide dimethyl acetal(4637-24-5)Raman

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Dimethoxy(dimethylamino)methane N,N-Dimethylfirmanmidedimethylacetal N,N-Dimethylformamide dimethyl acetal, ca 97% Methanamine, 1,1-dimethoxy-N,N-dimethyl- esterate m n,n-dimethylformamide dimethyl acetal solution N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL (DMF-DMA) 1,1-Dimethoxytrimethylamin N,N -DIMETHYL FORMAMIDE DIMETHYL ACETYL N,N'-Dimethylformanimide dimethyl acetal N,N-Dimethylformamide Dimethyl Acetal [for Esterification] (0.5ml*10) (Dimethylamino)formaldehyde Dimethoxy-N,N-dimethylmethylamine N,N-Dimethylformamide dimethyl acetal ,95% (Dimethylamino)formaldehyde dimethyl acetal Dimethyl(dimethoxymethyl)amine Dimethylaminomethanal dimethyl acetal N,N-Dimethyl-α,α-dimethoxymethanamine N,N-Dimethylformamide Dimethyl Acetal [for Esterification] 1,1-Dimethoxy-N,N-dimethylmethylamine, 1,1-Dimethoxytrimethylamine Trimethylamine, 1,1-dimethoxy- N,N-DIMETHYLDIMETHOXYMETHYLAMINE N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL N-DIMETHOXYMETHYL-N,N-DIMETHYLAMINE AURORA KA-683 METHYL-8 REAGENT METHYL-8(R) REAGENT METHYL-8 DMFDMA (DMFA) 1,1-DIMETHOXY-N,N-DIMETHYL METHANAMINE 1,1-DIMETHOXY-N,N-DIMETHYLMETHYLAMINE dimethylformamidediemthylacetal N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL, 9 4% N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL, D ERIVATIZATION GRADE DMFDMA [N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL] DmfDmaAcetal N,N-Dimethylformamide dimethyl acetal, 97+% N,N-dimethyl for mamide dimethyl acctel DMFDMA [N N-DiMethylforMaMide diMethyl acetal] N,N-DiMethylforMaMide diMethylacetal(DMFDA) N,N-DiMethylforMaMide diMethyl acetal, ca. 97% 100GR N,N-DiMethylforMaMide diMethyl acetal, ca. 97% 25GR N,N-DiMethylforMaMide diMethyl acetal, ca. 97% 500GR N,N-Dimethylformamide dimethyl acetal, ca. 97% N,N-Dimethylformamide Dimethyl Acetal￡¨DMADMF￡ N,N-DiMethylforMaMide diMethyl acetal, ca. 97%, AcroSeal N,N-DIMETHYLFORMAMIDE DIMETHYL ACETAL FO (Dimethoxymethyl)dimethylamine, 1,1-Dimethoxy-N,N-dimethylmethylamine N,N-two DMFtwoMethylal N,N-DiMethylforMaMide diMethyl acetal technical grade, 94% DiMethylfirManMidediMethylacetal(DMFDMA) N,N-Dimethylformamide dimethyl acetal N,N-Dimethylformamide dim Leflunomide Impurity 5 formamide dimethyL N,N-Dimethylformamide Dimethyl Acetal [for Esterification]> N,N-Dimethylformamide Dimethyl Acetal >