D-Homoserine, N-[(1,1-dimethylethoxy)carbonyl]- (9CI) synthesis
- Product Name:D-Homoserine, N-[(1,1-dimethylethoxy)carbonyl]- (9CI)
- CAS Number:745011-75-0
- Molecular formula:C9H17NO5
- Molecular Weight:219.24
6027-21-0
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24424-99-5
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745011-75-0
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Yield: 97.8%
Reaction Conditions:
with sodium hydroxide in ethanol;water at 20;
Steps:
5.1 Step 1 Preparation of Intermediate 5-1
Suspend (2R)-2-amino-4-hydroxy-butyric acid (10g, 83.95mmol) in EtOH (100mL) and H2O (50mL), then add (Boc)2O (19.22g, 88.15mmol) and NaOH (3.36g, 83.95mmol), stir overnight at room temperature, and spin-dry under reduced pressure to obtain crude intermediate 5-1 (18g, 82.10mmol, 97.80% yield),
References:
CN112341435, 2021, A Location in patent:Paragraph 0152-0155
67198-86-1
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745011-75-0
54 suppliers
$14.00/250mg