ChemicalBook CAS DataBase List 2-Propynoic acid, 3-(4-chlorophenyl)-, methyl ester

2-Propynoic acid, 3-(4-chlorophenyl)-, methyl ester synthesis

14synthesis methods

Product Name:2-Propynoic acid, 3-(4-chlorophenyl)-, methyl ester
CAS Number:7515-18-6
Molecular formula:C10H7ClO2
Molecular Weight:194.61

The synthesis of 2-Propynoic acid, 3-(4-chlorophenyl)-, methyl ester is as follows:
Into a 10 mL reaction tube was added 212 mg methyl-3-(4-chlorophenyl)-3-oxopropionic acid (1.0 mmol), 608 mg DBU (4.0 mmol), 7.5 mL DMSO, and a balloon filled with sulfuryl fluoride gas for a long time. In the form of a needle, air is bubbling below the liquid surface. The reaction system was reacted at room temperature for 3 hours. The progress of the reaction was detected by a thin layer chromatography plate. After the reaction was completed, the rotary evaporator was used to spin dry, and the residue was purified by silica gel column chromatography. The eluent was petroleum ether:ethyl acetate=10:1, to obtain methyl- 3-(4-Chlorophenyl)propynoic acid (165 mg, 85%).
synthesis of 2-Propynoic acid, 3-(4-chlorophenyl)-, methyl ester.png

synthesis of 2-Propynoic acid, 3-(4-chlorophenyl)-, methyl ester.png

22027-53-8 Synthesis

22027-53-8
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$60.00/50mg

2-Propynoic acid, 3-(4-chlorophenyl)-, methyl ester

7515-18-6
23 suppliers
$235.00/1G

Yield:7515-18-6 85%

Reaction Conditions:

with sulfur(VI) fluoride;1,8-diazabicyclo[5.4.0]undec-7-ene in (methylsulfinyl)methane at 20;

Steps:

7 Example 7:

Into a 10 mL reaction tube was added 212 mg methyl-3-(4-chlorophenyl)-3-oxopropionic acid (1.0 mmol), 608 mg DBU (4.0 mmol), 7.5 mL DMSO, and a balloon filled with sulfuryl fluoride gas for a long time. In the form of a needle, air is bubbling below the liquid surface. The reaction system was reacted at room temperature for 3 hours. The progress of the reaction was detected by a thin layer chromatography plate. After the reaction was completed, the rotary evaporator was used to spin dry, and the residue was purified by silica gel column chromatography. The eluent was petroleum ether:ethyl acetate=10:1, to obtain methyl- 3-(4-Chlorophenyl)propynoic acid (165 mg, 85%)

References:

CN114989035,2022,A Location in patent:Paragraph 0036-0040