5''-BROMOSPIRO[1,3-DIOXOLANE-2,3''-INDOL]-2''(1''H)-ONE synthesis
- Product Name:5''-BROMOSPIRO[1,3-DIOXOLANE-2,3''-INDOL]-2''(1''H)-ONE
- CAS Number:75822-54-7
- Molecular formula:C10H8BrNO3
- Molecular Weight:270.08
87-48-9
280 suppliers
$10.00/5g
107-21-1
1298 suppliers
$10.00/25g
75822-54-7
20 suppliers
$64.90/250mg
Yield:75822-54-7 99%
Reaction Conditions:
with toluene-4-sulfonic acid in toluene; for 5 h;Reflux;
Steps:
S'-bromospiroQl^dioxolane^S'-indolin^'-one (64).
To a solution of 5-bromoisatin (1 g, 4.42 mmol) in toluene (40 mL), ethylene glycol (4.9 mL, 84.48 mmol) and p-toluenesulphonic acid (38.1 mg, 0.22 mmol) were added. The reaction mixture was refluxed for 5 h and then evaporated to dryness. The residue was diluted with dichlomethane and washed with saturated sodium bicarbonate solution. The aqueous layer was extracted with dichloromethane three times. The combined organic extracts were dried over anhydrous sodium sulfate, filtered, and evaporated. The crude mixture was purified using column chromatography to yield 64. Yield: 99%. (C.H. Wang, A.R. White, S.N. Schwartz, S. Alluri, T.M. Cattabiani, L.K. Zhang, T.M. Chan, A.V. Buevich, A.K. Ganguly Tetrahedron 2012, 68, 9750-9762.)
References:
WO2014/85600,2014,A1 Location in patent:Paragraph 000163
87-48-9
280 suppliers
$10.00/5g
540-51-2
229 suppliers
$17.00/5g
75822-54-7
20 suppliers
$64.90/250mg
6714-68-7
29 suppliers
$30.00/20mg
75822-54-7
20 suppliers
$64.90/250mg
106-40-1
456 suppliers
$12.00/5g
75822-54-7
20 suppliers
$64.90/250mg
91-56-5
435 suppliers
$5.00/25g
75822-54-7
20 suppliers
$64.90/250mg