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ChemicalBook CAS DataBase List ETHYL 2-ANILINO-4-OXO-4,5-DIHYDRO-3-THIOPHENECARBOXYLATE
78267-15-9

ETHYL 2-ANILINO-4-OXO-4,5-DIHYDRO-3-THIOPHENECARBOXYLATE synthesis

2synthesis methods
-

Yield:78267-15-9 87%

Reaction Conditions:

Stage #1: ethyl (2-chloroaceto)acetatewith sodium hydride in 1,4-dioxane;mineral oil at 30;
Stage #2: phenyl isothiocyanate in 1,4-dioxane;mineral oil at 25 - 40;

References:

Bergman, Jan;Romero, Ivan [Journal of Heterocyclic Chemistry,2010,vol. 47,# 5,p. 1215 - 1220] Location in patent:experimental part