7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE, 1,4-DIHYDRO- synthesis
- Product Name:7H-PYRAZOLO[4,3-D]PYRIMIDIN-7-ONE, 1,4-DIHYDRO-
- CAS Number:13877-55-9
- Molecular formula:C5H4N4O
- Molecular Weight:136.11
923283-63-0
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3473-63-0
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13877-55-9
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$28.00/100mg
Yield: 89%
Reaction Conditions:
with N-ethyl-N,N-diisopropylamine in butan-1-ol at 110; for 1 h;
Steps:
17
Compound 27: Formamidine acetate (40.3 mmol, 4.2 g) was added to a solution containing 26 (8.85 g, 36.7 mmol) in Hunig's base (40 mL) and n-BuOH (40 mL). The stirred solution was heated at 110° C. for 1 hour. After cooling to ambient temperature the resulting solid was collected, washed with dichloromethane, and dried under reduced pressure to afford 27 (4.46 g, 89%), ES (+) MS m/e=137.
References:
Sunesis Pharmaceuticals, Inc. US2007/27166, 2007, A1 Location in patent:Page/Page column 84-85