8-Azabicyclo[3.2.1]octan-3-ol synthesis
- Product Name:8-Azabicyclo[3.2.1]octan-3-ol
- CAS Number:7432-11-3
- Molecular formula:C7H13NO
- Molecular Weight:127.18
![tert-Butyl 3-hydroxy-8-azabicyclo[3.2.1]octane-8-carboxylate](/CAS/20180629/GIF/478837-18-2.gif)
478837-18-2
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Yield:7432-11-3 100%
Reaction Conditions:
with hydrogenchloride in 1,4-dioxane;water at 25; for 12 h;
Steps:
51.1 Step 1: Preparation of 8-azabicyclo[3.2.1]octan-3-ol
A solution of tert-butyl 3-hydroxy-8-azabicyclo[3.2. 1]octane-8-carboxylate (322 mg, 1.41 mmol) in dioxane (4 M HC1 solution in Dioxane, 3 mL, 12 mmol) was stirred at 25 °C for 12hours. After the reaction was completed, the mixture was concentrated in vacuo to give 8-azabicyclo[3.2.1]octan-3-ol (180 mg, quant.) as a white solid. MS obsd. (ESI) [(M+H)]: 128.1.
References:
WO2020/79106,2020,A1 Location in patent:Page/Page column 95; 96
5632-84-8
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