ChemicalBook CAS DataBase List 8-Bromooctanoic acid

8-Bromooctanoic acid synthesis

11synthesis methods

Product Name:8-Bromooctanoic acid
CAS Number:17696-11-6
Molecular formula:C8H15BrO2
Molecular Weight:223.11

29823-21-0 Synthesis

29823-21-0
325 suppliers
$10.00/1g

17696-11-6
306 suppliers
$13.00/1g

Yield:17696-11-6 97%

Reaction Conditions:

with water;sodium hydroxide in ethanol at 0; for 5 h;

Steps:

8-Bromooctanoic Acid (17)

To a solution of ethyl 8-bromooctanoate (1.0 g, 3.98mmol) in EtOH (10 mL), 1M NaOH (3.98 mL) was addeddropwise, and the resulting mixture was stirred at 0°C for 5h. The mixture was acidified with 1M HCl and extractedwith ethyl acetate (3 10 mL). The organic layer waswashed with satd NaHCO3 (2 20 mL) and brine (2 20mL), dried over Na2SO4, filtered, and concentrated to getcompound 17 as colorless oil 0.86 g, yield 97%.

References:

Zhang, Liying;Dong, Jizhe;Zhang, Yingxia;Liu, Jun;Zhang, Luyong;Sun, Hongbin [Medicinal Chemistry,2013,vol. 9,# 2,p. 294 - 302]

50816-19-8 Synthesis