ChemicalBook CAS DataBase List 8-Chloro-3-iodoimidazo[1,2-a]pyrazine

8-Chloro-3-iodoimidazo[1,2-a]pyrazine synthesis

3synthesis methods

Product Name:8-Chloro-3-iodoimidazo[1,2-a]pyrazine
CAS Number:1049677-32-8
Molecular formula:C6H3ClIN3
Molecular Weight:279.47

8-chloroimidazo[1,2-a]pyrazine (5.2 g, 33.9 mmol) and N-iodo-succinimide (NIS) (8 g, 35.6 mmol) were combined with DMF (34 ml). The reaction mixture was stirred at RT for 48 h. After that, the water was added to the suspension, and the solid was filtered, washed with water and MeOH, and dried under HV to afford 8-Chloro-3-iodoimidazo[1,2-a]pyrazine (7.17 g, 25.6 mmol, 75.8% yield).

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Yield:1049677-32-8 75.8%

Reaction Conditions:

with N-iodo-succinimide in N,N-dimethyl-formamide at 20; for 48 h;Inert atmosphere;

Steps:

1.1 8-chloro-3-iodoimidazo[1,2-a]pyrazine

8-chloroimidazo[1,2-a]pyrazine (5.2 g, 33.9 mmol, Eq: 1) and NIS (8 g, 35.6 mmol, Eq: 1.05) were combined with DMF (34 ml). The reaction mixture was stirred at RT for 48 h. Water was added to the suspension and the solid was filtered, washed with water and MeOH and dried under HV to afford the title compound (7.17 g, 25.6 mmol, 75.8% yield) as an off-white solid. MS (ESI, m/z): 280.0 [M+H]⁺.

References:

WO2021/249896,2021,A1 Location in patent:Page/Page column 51-53

105076-76-4 Synthesis

N-(4-AMINOPHENYL)-2-MORPHOLIN-4-YLACETAMIDE

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References

4-Morpholineacetamide, N-(4-nitrophenyl)-

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References

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