4-Chloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid synthesis
- Product Name:4-Chloro-1-methyl-6-oxo-1,6-dihydropyridine-3-carboxylic acid
- CAS Number:821791-59-7
- Molecular formula:C7H6ClNO3
- Molecular Weight:187.58
821791-58-6
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$53.00/250mg
821791-59-7
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$338.00/1g
Yield:821791-59-7 60%
Reaction Conditions:
with water;sodium hydroxide in tetrahydrofuran;methanol at 20; for 3 h;
Steps:
35.1 (Step 1) Preparation of 4-chloro- 1 -methyl-6-oxo- 1 ,6-dihydropyridine-3-carboxylic acid
Ethyl 4-chloro- 1 -methyl-6-oxo- 1 ,6-dthydropyridine-3-carboxylate (300 mg, 1.0 eq) dissolved in a mixed solvent of tetrahydrofuran/methanol (7 mL/ 7 mL) was added with 2 N sodium hydroxide (4 mL), and stirred at room temperature for 3 hours. Upon completion of the reaction, the resultant was diluted with ethyl acetate and water to separate the aqueous layer. The resulting aqueous layer was acidified with 2 N HC1 to form crystals. The resulting crystals were filtered to obtain a title compound (yield;60%).
References:
WO2015/60613,2015,A1 Location in patent:Paragraph 353; 354
853105-37-0
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821791-59-7
12 suppliers
$338.00/1g
105-50-0
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$6.00/5g
821791-59-7
12 suppliers
$338.00/1g