
Tert-Butyl 6-(Hydroxymethyl)-3-Azabicyclo[3.1.0]Hexane-3-Carboxylate synthesis
- Product Name:Tert-Butyl 6-(Hydroxymethyl)-3-Azabicyclo[3.1.0]Hexane-3-Carboxylate
- CAS Number:850808-43-4
- Molecular formula:C11H19NO3
- Molecular Weight:213.27
![3-Azabicyclo[3.1.0]hexane-6-methanol, 3-(phenylmethyl)-](/CAS/20180703/GIF/871727-08-1.gif)
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![Tert-Butyl 6-(Hydroxymethyl)-3-Azabicyclo[3.1.0]Hexane-3-Carboxylate](/CAS/20180527/GIF/850808-43-4.gif)
850808-43-4
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$55.00/25mg
Yield: 76%
Reaction Conditions:
with palladium 10% on activated carbon;hydrogen in methanol at 25; under 760.051 Torr; for 16 h;
Steps:
33D Example 33D tert-butyl 6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate
Example 33D
tert-butyl 6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate
A mixture of EXAMPLE 33C (1.42 g, 7.0 mmol), Boc2O (1.81 g, 8.4 mmol) and 10% Pd/C (200 mg) in methanol (80 mL) was hydrogenated at 25° C. for 16 h under H2 (1 atm).
The mixture was filtered and the filtrate was evaporated to give the residue which was purified by chromatography to provide the title compound 4 (1.14 g, 76%). LCMS (ESI) m/z: 214 (M+1).
References:
HUMANWELL HEALTHCARE (GROUP) CO., LTD.;HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE INC.;MEDSHINE DISCOVERY INC.;WANG, Xuehai;DING, Zhaozhong;XU, Yong;CHEN, Shuhui;LI, Lie;LI, Gang;TU, Ronghua;WANG, Cailin;YUE, Yang;ZHANG, Zhibo;CHEN, Hailiang;SUN, Wenjie;HUANG, Lu US2017/29430, 2017, A1 Location in patent:Paragraph 0385
![3-AZA-BICYCLO[3.1.0]HEXAN-6-YLMENTHOL](/CAS/GIF/289037-48-5.gif)
289037-48-5
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![Tert-Butyl 6-(Hydroxymethyl)-3-Azabicyclo[3.1.0]Hexane-3-Carboxylate](/CAS/20180527/GIF/850808-43-4.gif)
850808-43-4
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$55.00/25mg

24424-99-5
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$13.50/25G
![(1R,5S,6R)-3-azabicyclo[3.1.0]hexan-6-ylmethanol](/CAS/GIF/134575-13-6.gif)
134575-13-6
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![Tert-Butyl 6-(Hydroxymethyl)-3-Azabicyclo[3.1.0]Hexane-3-Carboxylate](/CAS/20180527/GIF/850808-43-4.gif)
850808-43-4
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$55.00/25mg
![3-AZABICYCLO[3.1.0]HEXAN-6-YLMETHANOL HCL](/CAS/20180529/GIF/850808-44-5.gif)
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![Tert-Butyl 6-(Hydroxymethyl)-3-Azabicyclo[3.1.0]Hexane-3-Carboxylate](/CAS/20180527/GIF/850808-43-4.gif)
850808-43-4
17 suppliers
$55.00/25mg
![3-Azabicyclo[3.1.0]hexane-6-methanol, 3-(phenylmethyl)-](/CAS/20180703/GIF/871727-08-1.gif)
871727-08-1
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![Tert-Butyl 6-(Hydroxymethyl)-3-Azabicyclo[3.1.0]Hexane-3-Carboxylate](/CAS/20180527/GIF/850808-43-4.gif)
850808-43-4
17 suppliers
$55.00/25mg