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18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
850808-43-4

Tert-Butyl 6-(Hydroxymethyl)-3-Azabicyclo[3.1.0]Hexane-3-Carboxylate synthesis

7synthesis methods
871727-08-1 Synthesis
3-Azabicyclo[3.1.0]hexane-6-methanol, 3-(phenylmethyl)-

871727-08-1
10 suppliers
inquiry

24424-99-5 Synthesis
Di-tert-butyl dicarbonate

24424-99-5
863 suppliers
$13.50/25G

Tert-Butyl 6-(Hydroxymethyl)-3-Azabicyclo[3.1.0]Hexane-3-Carboxylate

850808-43-4
17 suppliers
$55.00/25mg

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Yield: 76%

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen in methanol at 25; under 760.051 Torr; for 16 h;

Steps:

33D Example 33D tert-butyl 6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate
Example 33D
tert-butyl 6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate
A mixture of EXAMPLE 33C (1.42 g, 7.0 mmol), Boc2O (1.81 g, 8.4 mmol) and 10% Pd/C (200 mg) in methanol (80 mL) was hydrogenated at 25° C. for 16 h under H2 (1 atm).
The mixture was filtered and the filtrate was evaporated to give the residue which was purified by chromatography to provide the title compound 4 (1.14 g, 76%). LCMS (ESI) m/z: 214 (M+1).

References:

HUMANWELL HEALTHCARE (GROUP) CO., LTD.;HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE INC.;MEDSHINE DISCOVERY INC.;WANG, Xuehai;DING, Zhaozhong;XU, Yong;CHEN, Shuhui;LI, Lie;LI, Gang;TU, Ronghua;WANG, Cailin;YUE, Yang;ZHANG, Zhibo;CHEN, Hailiang;SUN, Wenjie;HUANG, Lu US2017/29430, 2017, A1 Location in patent:Paragraph 0385

3-AZA-BICYCLO[3.1.0]HEXAN-6-YLMENTHOL

289037-48-5
36 suppliers
$498.88/5MG

24424-99-5 Synthesis
Di-tert-butyl dicarbonate

24424-99-5
863 suppliers
$13.50/25G

Tert-Butyl 6-(Hydroxymethyl)-3-Azabicyclo[3.1.0]Hexane-3-Carboxylate

850808-43-4
17 suppliers
$55.00/25mg

References
24424-99-5 Synthesis
Di-tert-butyl dicarbonate

24424-99-5
863 suppliers
$13.50/25G

(1R,5S,6R)-3-azabicyclo[3.1.0]hexan-6-ylmethanol

134575-13-6
90 suppliers
$60.00/100mg

Tert-Butyl 6-(Hydroxymethyl)-3-Azabicyclo[3.1.0]Hexane-3-Carboxylate

850808-43-4
17 suppliers
$55.00/25mg

References
850808-44-5 Synthesis
3-AZABICYCLO[3.1.0]HEXAN-6-YLMETHANOL HCL

850808-44-5
3 suppliers
inquiry

24424-99-5 Synthesis
Di-tert-butyl dicarbonate

24424-99-5
863 suppliers
$13.50/25G

Tert-Butyl 6-(Hydroxymethyl)-3-Azabicyclo[3.1.0]Hexane-3-Carboxylate

850808-43-4
17 suppliers
$55.00/25mg

References
871727-08-1 Synthesis
3-Azabicyclo[3.1.0]hexane-6-methanol, 3-(phenylmethyl)-

871727-08-1
10 suppliers
inquiry

Tert-Butyl 6-(Hydroxymethyl)-3-Azabicyclo[3.1.0]Hexane-3-Carboxylate

850808-43-4
17 suppliers
$55.00/25mg

References