4-((4-Methylpiperazin-1-yl)Methyl)-3-(trifluoroMethyl)benzoic acid synthesis
- Product Name:4-((4-Methylpiperazin-1-yl)Methyl)-3-(trifluoroMethyl)benzoic acid
- CAS Number:859027-02-4
- Molecular formula:C14H18ClF3N2O2
- Molecular Weight:338.76
896160-80-8
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859027-02-4
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Yield:859027-02-4 100%
Reaction Conditions:
with lithium hydroxide monohydrate;lithium hydroxide monohydrate in tetrahydrofuran; for 4 h;Reflux;
Steps:
General procedure for saponification
General procedure: General procedure for saponification: Ester derivative was dissolved in THF (0.8 mol/L) and a water solution of LiOH (3 eq) was added. Mixture was heated to reflux for 4 h. THF was evaporated and impurities were extracted with EtOAc at pH = 12. Aqueous layer was saturated with NaCl(s) and acidified until pH = 3 with HC1 6 N. Product was extracted with Butan-l-ol. Butan-l-ol was evaporated and the solid obtained was washed with EtOAc to remove salts and impurities. A white solid was obtained.
References:
WO2014/102378,2014,A1 Location in patent:Page/Page column 50
![Benzoic acid, 4-[(4-methyl-1-piperazinyl)methyl]-3-(trifluoromethyl)-, ethyl ester](/CAS/20210305/GIF/859027-00-2.gif)
859027-00-2
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859027-02-4
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859213-39-1
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109-01-3
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859027-02-4
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109-01-3
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863248-28-6
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859027-02-4
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261952-01-6
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859027-02-4
21 suppliers
$657.20/250mg