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ChemicalBook CAS DataBase List 4-Methyl-3-(trifluoromethyl)benzoic acid

4-Methyl-3-(trifluoromethyl)benzoic acid synthesis

1synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: silver carbonate; sodium carbonate; dipotassium peroxodisulfate / dichloromethane / 10 h / 120 °C / Schlenk technique; Sealed tube
2: sodium hydroxide; water / ethanol / 6 h / Reflux

References:

Shi, Guangfa;Shao, Changdong;Pan, Shulei;Yu, Jingxun;Zhang, Yanghui [Organic Letters,2015,vol. 17,# 1,p. 38 - 41]

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