1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene synthesis
- Product Name:1,3-dichloro-5-(3,3,3-trifluoroprop-1-en-2-yl)benzene
- CAS Number:864725-22-4
- Molecular formula:C9H5Cl2F3
- Molecular Weight:241.04
2065-66-9
322 suppliers
$5.00/5g
130336-16-2
368 suppliers
$7.00/100mg
864725-22-4
120 suppliers
inquiry
Yield:864725-22-4 79%
Reaction Conditions:
with potassium tert-butylate in tetrahydrofuran at 20 - 25; for 1.5 h;Product distribution / selectivity;
Steps:
S.8
To a suspension of methyl-triphenylphosphonium bromide (16.17 g, 25.27 mmol) and 3,5-dichloro-2,2,2-trifluoro acetophenone (10.0 g, 41 .15 mmol) in THF (65 mL) was added KOtBu (5.54 g, 49.38 mmol) in THF (28 mL) at 20-25°C. After 1 .5 h at room temp, the reaction was complete by GC. The mixture was separated between n- heptane and water. The organic layer was separated, washed with brine and the solvent was removed in vacuum. After cooling, the mixture was filtered from precipitating triphenylphosphine oxide to yield the title compound (8.78 g, 79%).1H-NM R (360 M Hz, CDCI3): δ = 5.82 (s, 1 H), 6.06 (s, 1 H), 7.32 (s, 2H), 7.38 (s, 1 H) ppm.
References:
BASF SE;KÖRBER, Karsten;KORDES, Markus;RACK, Michael;VON DEYN, Wolfgang;KAISER, Florian WO2012/59441, 2012, A2 Location in patent:Page/Page column 51
1514-82-5
259 suppliers
$45.00/5 g
67492-50-6
350 suppliers
$6.00/1g
864725-22-4
120 suppliers
inquiry
1779-49-3
629 suppliers
$5.00/10g
130336-16-2
368 suppliers
$7.00/100mg
864725-22-4
120 suppliers
inquiry
1031-15-8
202 suppliers
$7.00/5g
130336-16-2
368 suppliers
$7.00/100mg
864725-22-4
120 suppliers
inquiry
677-21-4
135 suppliers
$35.00/25 g
67492-50-6
350 suppliers
$6.00/1g
864725-22-4
120 suppliers
inquiry