N-[(1R)-3-(DiMethylaMino)-3-oxo-1-[(phenylthio)Methyl]propyl]carbaMic Acid PhenylMethyl Ester synthesis
- Product Name:N-[(1R)-3-(DiMethylaMino)-3-oxo-1-[(phenylthio)Methyl]propyl]carbaMic Acid PhenylMethyl Ester
- CAS Number:870812-30-9
- Molecular formula:C20H24N2O3S
- Molecular Weight:372.48
![N-[(1R)-3-(Dimethylamino)-1-(hydroxymethyl)-3-oxopropyl]carbamic Acid Phenylmethyl Ester](/CAS2/GIF/870812-29-6.gif)
870812-29-6
15 suppliers
$120.09/10mg
882-33-7
312 suppliers
$10.00/5g
870812-30-9
17 suppliers
$95.00/5mg
Yield:870812-30-9 95%
Reaction Conditions:
with tributylphosphine in toluene at 80; for 16 h;
Steps:
1.1K benzyl (1R)-3-(dimethylamino)-3-oxo-1-((phenylsulfanyl)methyl)propylcarbamate
EXAMPLE 1K benzyl (1R)-3-(dimethylamino)-3-oxo-1-((phenylsulfanyl)methyl)propylcarbamate A solution of EXAMPLE 1J (8.45 g, 30.14 mmol) in toluene (15 mL) was treated with tributylphosphine (9.76 mL, 39.20 mmol), diphenyldisulfide (7.30 g, 39.20 mmol) and heated to 80° C. for 16 hours. The reaction mixture was concentrated and purified by column chromatography on silica gel eluding with a gradient of 0-50% ethyl acetate in hexanes to give the desired product (10.62 g, 95%). MS (CI) m/e 373 (M+H)+.
References:
US2005/272744,2005,A1 Location in patent:Page/Page column 11-12
118399-28-3
137 suppliers
$6.00/100mg
124-40-3
534 suppliers
$18.00/100ml
882-33-7
312 suppliers
$10.00/5g
870812-30-9
17 suppliers
$95.00/5mg
![Carbamic acid, N-[(1R)-3-(dimethylamino)-1-[[(methylsulfonyl)oxy]methyl]-3-oxopropyl]-, phenylmethyl ester](/CAS/20210111/GIF/1027345-10-3.gif)
1027345-10-3
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inquiry
108-98-5
0 suppliers
$26.30/10g
870812-30-9
17 suppliers
$95.00/5mg
75443-62-8
34 suppliers
$112.00/100mg
870812-30-9
17 suppliers
$95.00/5mg
118399-28-3
137 suppliers
$6.00/100mg
870812-30-9
17 suppliers
$95.00/5mg