6-Chloro-N-(tetrahydro-2-furanylmethyl)-4-pyrimidinamine synthesis

Yield:872512-18-0 56%

Reaction Conditions:

with N-ethyl-N,N-diisopropylamine in butan-1-ol at 80; for 16 h;

Steps:

1-1 1-1. Preparation of 6-chloro-4- (tetrahydrofuran-2-yl) methylaminopyrimidine

4,6-Dichloropyrimidine (1 g, 6.71 mmol) was added to a round bottom flask and dissolved in n-butanol (40 mL)(Tetrahydrofuran-2-yl) methanamine (0.69 mL, 6.71 mmol) and diisopropylethylamine (3.5 mL, 20.1 mmol) were added and the mixture was stirred at 80 ° C for 16 hours.When the reaction was completed, the solvent was removed by distillation under reduced pressure, water was added to the reaction mixture, and the mixture was extracted with dichloromethane.After drying with anhydrous magnesium sulfate, the solvent was removed by distillation under reduced pressure, and the resultant product was purified by column chromatography to obtain the title compound (0.8 g, 56%).

References:

KR101916773,2018,B1 Location in patent:Paragraph 0110-0113