3,5-Difluoro-4-Methoxybenzeneboronic acid pinacol ester, 96% synthesis
- Product Name:3,5-Difluoro-4-Methoxybenzeneboronic acid pinacol ester, 96%
- CAS Number:890839-37-9
- Molecular formula:C13H17BF2O3
- Molecular Weight:270.08
104197-14-0
179 suppliers
$15.00/250mg
73183-34-3
590 suppliers
$6.00/5g
890839-37-9
16 suppliers
$132.00/250mg
Yield:890839-37-9 90%
Reaction Conditions:
with potassium acetate;dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2 in 1,4-dioxane;dichloromethane at 80; for 12.5 h;Inert atmosphere;
Steps:
112
Intermediate 112 2-(3,5-difluoro-4-methoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxa borolane To a solution of intermediate 111 (2.0 g, 8.968 mmoles) in Dioxan (40 ml), bis(pinacaloto)diboron (2.73 g, 10.76 mmoles) and potassium acetate (2.64 g, 26.90 mmoles) were added and the system is degassed for 30 min Bis(diphenylphosphinoferrocene)dichloro palladium.CH2Cl2 (0.219 g, 0.269 mmoles) was added under nitrogen atmosphere and heated to 80° C. After 12 h, the reaction mixture filtered through celite and concentrated. The crude product was purified by column chromatography with ethyl acetate:petroleum ether to afford the title compound as yellow liquid (2.2 g, 90% yield).). 1H-NMR (δ ppm, DMSO-d6, 400 MHz): δ δ 7.318 (d, J=8.7 Hz, 2H), 4.02 (s, 3H), 1.32 (s, 12H).
References:
US2011/118257,2011,A1 Location in patent:Page/Page column 100
28177-48-2
313 suppliers
$15.00/5g
890839-37-9
16 suppliers
$132.00/250mg
104197-13-9
245 suppliers
$6.00/1g
890839-37-9
16 suppliers
$132.00/250mg
104197-14-0
179 suppliers
$15.00/250mg
73183-34-3
590 suppliers
$6.00/5g
890839-37-9
16 suppliers
$132.00/250mg
208641-98-9
77 suppliers
$23.00/100mg