Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
logo
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
My chemicalbook

Welcome back!

Structured search
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
ChemicalBook CAS DataBase List 4-Bromo-2,6-difluorophenol
104197-13-9

4-Bromo-2,6-difluorophenol synthesis

5synthesis methods
To a solution of 2,6-Difluorophenol (10.0 g, 76.86 mmol) in DMF (60 mL), N-bromosuccinimide (13.68 g, 76.86 mmol) was added at 0° C. and stirred at RT for 20 h. The reaction mixture was concentrated, diluted with water and extracted with ethyl acetate. The organic layer was dried over sodium sulphate and concentrated under reduced pressure to afford 4-Bromo-2,6-difluorophenol as a light yellow liquid (15.1 g, 93 percent yield). 1H-NMR (δ ppm, DMSO-D6, 400 MHz): δ 10.49 (s, 1H), 7.35 (d, J=6.2 Hz, 2H).
28177-48-2 Synthesis
2,6-Difluorophenol

28177-48-2
310 suppliers
$15.00/5g

4-Bromo-2,6-difluorophenol

104197-13-9
242 suppliers
$6.00/1g

-

Yield:104197-13-9 93%

Reaction Conditions:

with N-Bromosuccinimide in N,N-dimethyl-formamide at 0 - 20; for 20 h;

Steps:

110

Intermediate 110 4-bromo-2,6-difluorophenol To a solution of 2,6-Difluorophenol (10.0 g, 76.86 mmoles) in DMF (60 mll), N-bromosuccinimide (13.68 g, 76.86 mmoles) was added at 0° C. and stirred at RT for 20 h. The reaction mixture was concentrated, diluted with water and extracted with ethyl acetate. The organic layer was dried over sodium sulphate and concentrated under reduced pressure to afford the title compound as light yellow liquid (15.1 g, 93% yield). 1H-NMR (δ ppm, DMSO-D6, 400 MHz): δ 10.49 (s, 1H), 7.35 (d, J=6.2 Hz, 2H).

References:

US2011/118257,2011,A1 Location in patent:Page/Page column 100

461-96-1 Synthesis
1-Bromo-3,5-difluorobenzene

461-96-1
482 suppliers
$6.00/10g

4-Bromo-2,6-difluorophenol

104197-13-9
242 suppliers
$6.00/1g

References
4-Bromophenol

106-41-2
500 suppliers
$13.00/5g

2105-94-4 Synthesis
4-Bromo-2-fluorophenol

2105-94-4
365 suppliers
$6.00/5g

4-Bromo-2,6-difluorophenol

104197-13-9
242 suppliers
$6.00/1g

References
1,3-Difluorobenzene

372-18-9
425 suppliers
$9.00/1g

4-Bromo-2,6-difluorophenol

104197-13-9
242 suppliers
$6.00/1g

References
162101-25-9 Synthesis
2,6-Difluorophenylboronic acid

162101-25-9
333 suppliers
$6.00/1g

4-Bromo-2,6-difluorophenol

104197-13-9
242 suppliers
$6.00/1g

References

4-Bromo-2,6-difluorophenol Related Search:

5-Bromo-2,3-difluoroanisole 4-BROMO-2,5-DIFLUOROPHENOL 4-Amino-3-fluorophenol 2-BROMO-3,5-DIFLUOROPHENOL 2-Bromo-4,6-difluorophenol 4-Bromo-2,3-difluorophenol 2,6-Difluorophenol 4-BROMOTETRAFLUOROPHENOL