Quinazoline, 4-chloro-7-methoxy-6-[3-(4-methyl-1-piperazinyl)propoxy]- synthesis
- Product Name:Quinazoline, 4-chloro-7-methoxy-6-[3-(4-methyl-1-piperazinyl)propoxy]-
- CAS Number:894426-67-6
- Molecular formula:C17H23ClN4O2
- Molecular Weight:350.84
5317-33-9
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Yield:894426-67-6 73%
Reaction Conditions:
with di-tert-butyl-diazodicarboxylate;triphenylphosphine in tetrahydrofuran at 20; for 12 h;Mitsunobu reaction;
References:
Tasler, Stefan;Mueller, Oliver;Wieber, Tanja;Herz, Thomas;Pegoraro, Stefano;Saeb, Wael;Lang, Martin;Krauss, Rolf;Totzke, Frank;Zirrgiebel, Ute;Ehlert, Jan E.;Kubbutat, Michael H.G.;Schaechtele, Christoph [Bioorganic and Medicinal Chemistry,2009,vol. 17,# 18,p. 6728 - 6737] Location in patent:supporting information; experimental part