4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-([2-(trimethylsilyl)ethoxy]methyl)-1H-pyrazole synthesis
- Product Name:4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)-1-([2-(trimethylsilyl)ethoxy]methyl)-1H-pyrazole
- CAS Number:894807-98-8
- Molecular formula:C15H29BN2O3Si
- Molecular Weight:324.3
269410-08-4
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$5.00/1g
76513-69-4
362 suppliers
$6.00/1g
894807-98-8
74 suppliers
$98.00/100mg
Yield: 86%
Reaction Conditions:
with potassium carbonate in 1-methyl-pyrrolidin-2-one at 20; for 16 h;Inert atmosphere;
Steps:
15.A
Synthesis of 4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2~yl)-1-((2- (trimethylsilyl)ethoxy)methyl)-1 t-15a)lnt-15aTo a solution of 4-(4,4,5,5-tetramethyl-1 ,3,2-dioxaborolan-2-yl)- H- pyrazole (8.2 g, 41 mmol) in NMP (60 mL) was added K2C03 (12 g, 82 mmoi) and 2-(trimethylsilyi)ethoxymethy. chloride (7.8 mL, 43 mmol) in sequence. The reaction mixture was stirred at r.t. under N2 for 16 h. Then, the reaction mixture was diluted and filtered, and then the filtrate was diluted with EtOAc (300 mL). The resulting solution was washed with sat. NaHC03 (aq) (3 x 200 mL), H20 (4 x 200 mL), brine (1 x 200 mL), dried over Na2S04, filtered, concentrated and dried in vacuo to yield intermediate .nt-15a (11.4 g, 86 %) as a clear yellowish oil.
References:
SCHERING CORPORATION;TSUI, Hon-Chung;PALIWAL, Sunil;KIM, Hyunjin, M.;KEREKES, Angela, D.;CAPLEN, Mary Ann;ESPOSITE, Sara, J.;MCKITTRICK, Brian, A.;FISCHMANN, Thierry Olivier;DOLL, Ronald, J.;RAINKA, Matthew Paul;LI, Ang WO2011/149874, 2011, A2 Location in patent:Page/Page column 81-82
76513-69-4
362 suppliers
$6.00/1g
894807-98-8
74 suppliers
$98.00/100mg
73183-34-3
593 suppliers
$6.00/5g
894807-98-8
74 suppliers
$98.00/100mg