4-(Naphthalenyl)-N-[4-(1-naphthalenyl)phenyl]benzenamine synthesis

Yield:897671-74-8 75%

Reaction Conditions:

with tris-(dibenzylideneacetone)dipalladium⁽⁰⁾;tri-tert-butyl phosphine;sodium t-butanolate in toluene at 120; for 10 h;Inert atmosphere;

Steps:

3.1 Step 1: Synthesis of Intermediate 7-1

Add 4-(1-naphthyl)aniline (10.4g, 47.4mmol), 1-(4-bromophenyl)naphthalene (13.4g, 47.4mmol), and sodium tert-butoxide (9.1g, 94.8mmol) into the reaction flask in,Replace with nitrogen 3 times, add toluene (100ml) under nitrogen protection, and replace 3 times with nitrogen,Add tris(dibenzylideneacetone) bispalladium (0.43g, 0.474mmol) under nitrogen protection,50% tri-tert-butyl phosphine (0.38g, 0.948mmol), nitrogen replacement 3 times,The temperature was raised to 120°C and stirred for 10h. Cool to room temperature, add 100ml of water and stir for 30min,The solid compound was dried by suction filtration, and 15 g of solid compound was obtained by separation and purification by column chromatography with a yield of 75%.

References:

CN112961134,2021,A Location in patent:Paragraph 0071-0074