tetrahydro-2H-thiopyran-4-carbonitrile 1,1-dioxide(SALTDATA: FREE) synthesis

Yield:-

Reaction Conditions:

with 3-chloro-benzenecarboperoxoic acid in chloroform at 0 - 20; for 3 h;

Steps:

3 Reference Example 3

A chloroform solution of tetrahydro-2H-thiopyran-4-carbonitrile was dropwise added to a chloroform solution of 77% m-chloroperbenzoic acid at 0°C, followed by stirring at room temperature for 3 hours. An excess amount of an aqueous saturated sodium sulfite solution was added , followed by work-up to obtain tetrahydro-2H-thiopyran-4-carbonitrile 1,1-dioxide.

References:

EP1864976,2007,A1 Location in patent:Page/Page column 18