(S)-2-tert-butoxycarbonylamino-5-oxo-hexanoic acid ethyl ester synthesis

Yield:-

Steps:

Multi-step reaction with 2 steps
1: CH₂Cl₂ / 20 °C
2: tetrahydrofuran / -40 - -20 °C

References:

Pei, Zhonghua;Li, Xiaofeng;Longenecker, Kenton;Von Geldern, Thomas W.;Wiedeman, Paul E.;Lubben, Thomas H.;Zinker, Bradley A.;Stewart, Kent;Ballaron, Stephen J.;Stashko, Michael A.;Mika, Amanda K.;Beno, David W. A.;Long, Michelle;Wells, Heidi;Kempf-Grote, Anita J.;Madar, David J.;McDermott, Todd S.;Bhagavatula, Lakshmi;Fickes, Michael G.;Pireh, Daisy;Solomon, Larry R.;Lake, Marc R.;Edalji, Rohinton;Fry, Elizabeth H.;Sham, Hing L.;Trevillyan, James M. [Journal of Medicinal Chemistry,2006,vol. 49,# 12,p. 3520 - 3535]