Cholan-24-oic acid,6-ethyl-3-hydroxy-7-oxo-,(3α,5β,6β)- synthesis
- Product Name:Cholan-24-oic acid,6-ethyl-3-hydroxy-7-oxo-,(3α,5β,6β)-
- CAS Number:915038-25-4
- Molecular formula:C26H42O4
- Molecular Weight:418.61
915038-24-3
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915038-25-4
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Yield:915038-25-4 99.1%
Reaction Conditions:
with palladium 10% on activated carbon;ammonium formate in ethanol at 20; for 3 h;Reagent/catalyst;Solvent;
Steps:
1 Example 1: Synthesis of a cholestyryl intermediate compound of formula 2
Add in a 100mL three-neck bottle3α-hydroxy-6-methylene-7-keto-5β-cholanoic acid (5.50 g, 13.20 mmol),Ammonium formate (1.66 g, 26.40 mmol) and 55 mL of ethanol,Then wet Pd/C (0.55 g) having a palladium content of 10% was added.The reaction was carried out at room temperature for 3 h.Filter the reaction solution,The filter cake is washed with ethanol,The filtrate was concentrated under reduced pressure at 50 °C.Obtaining a compound of formula 2 as a white solid,5.48g,The yield was 99.1%
References:
CN108117579,2018,A Location in patent:Paragraph 0028; 0029; 0031; 0033; 0035; 0037; 0039; 0041
863239-59-2
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915038-25-4
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77341-09-4
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$452.00/250mg
915038-25-4
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4651-67-6
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$39.00/500mg
915038-25-4
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