(S)-tert-Butyl (1-(5-bromopyridin-2-yl)ethyl)carbamate synthesis
- Product Name:(S)-tert-Butyl (1-(5-bromopyridin-2-yl)ethyl)carbamate
- CAS Number:915720-71-7
- Molecular formula:C12H17BrN2O2
- Molecular Weight:301.18
915720-70-6
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915720-71-7
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Yield:915720-71-7 68.5%
Reaction Conditions:
with triethylamine in dichloromethane at 20; for 16 h;
Steps:
Intermediate 61: (5)-tert-butyl (1 -(5-bromopyridi n-2-yl)ethyl)carbamate
Intermediate 61: (5)-tert-butyl (1 -(5-bromopyridi n-2-yl)ethyl)carbamate To a solution of (S)-1-(5-bromopyridin-2-yl)ethanamine (300 mg, 1.49 mmol) in DCM (7.5 mL)was added di-tert-butyl dicarbonate (358 mg, 1.64 mmol) and triethylamine (0.31 mL, 2.24mmol). The solution was stirred for 16 h at room temperature then washed with water andbrine. The organic layer was dried over Na2SO4, filtered and concentrated. Silica gel columnchromatography (EtOAc/heptane 0 to 80%) provided a white solid (308 mg, 68.5% yield).1H NMR (400 MHz, CDCI3) O 8.59 (d, J= 2.2 Hz, 1H), 7.76 (dd, J= 8.3, 2.4 Hz, 1H), 7.16 (d, J= 8.3 Hz, 1H), 5.57- 5.42 (m, 1H), 4.86- 4.73 (m, 1H), 1.43 (t, J= 3.4 Hz, 12H); MS m/z 303.4(M+H).
References:
WO2014/141153,2014,A1 Location in patent:Page/Page column 69; 70
915720-70-6
31 suppliers
$338.00/250mg
915720-71-7
27 suppliers
$91.00/100mg
![Acetamide, N-[1-(5-bromo-2-pyridinyl)ethenyl]-](/CAS/20210305/GIF/915720-73-9.gif)
915720-73-9
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915720-71-7
27 suppliers
$91.00/100mg
97483-77-7
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915720-71-7
27 suppliers
$91.00/100mg
31181-90-5
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915720-71-7
27 suppliers
$91.00/100mg