2,4(1H,3H)-Pyrimidinedione, 1,3-dimethyl-6-[(3,4,5,6-tetrahydro-2H-azepin-7-yl)amino]- synthesis

1synthesis methods

Product Name:2,4(1H,3H)-Pyrimidinedione, 1,3-dimethyl-6-[(3,4,5,6-tetrahydro-2H-azepin-7-yl)amino]-
CAS Number:929975-78-0
Molecular formula:C12H18N4O2
Molecular Weight:250.3

2525-16-8 Synthesis

2525-16-8
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6642-31-5 Synthesis

6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

6642-31-5
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2,4(1H,3H)-Pyrimidinedione, 1,3-dimethyl-6-[(3,4,5,6-tetrahydro-2H-azepin-7-yl)amino]-

929975-78-0
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Yield:929975-78-0 51%

Reaction Conditions:

in N,N-dimethyl-formamide at 150;regioselective reaction;

Steps:

4 General procedure for the preparation of 7ba-dc

General procedure: 6-Aminouracil (0.1 mol), iminoether (0.3 mol), and DMF (1 mL) was heated until homogenous solution appeared and after that was refluxed for additional 4 h. Then the mixture was concentrated and treated with Et₂O (100 mL). The precipitate was filtered and purified by crystallization from the specified solvent.

References:

Liubchak, Kostiantyn;Tolmachev, Andrey;Grygorenko, Oleksandr O.;Nazarenko, Kostiantyn [Tetrahedron,2012,vol. 68,# 41,p. 8564 - 8571]