ChemicalBook CAS DataBase List 6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione synthesis

12synthesis methods

Product Name:6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione
CAS Number:6642-31-5
Molecular formula:C6H9N3O2
Molecular Weight:155.15

873-83-6 Synthesis

873-83-6
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$9.00/25g

74-88-4
339 suppliers
$15.00/10g

6-Amino-1,3-dimethyl-1,2,3,4-tetrahydropyrimidine-2,4-dione

6642-31-5
370 suppliers
$5.00/10g

Yield:6642-31-5 90%

Reaction Conditions:

Stage #1:4-Amino-2,6-dihydroxypyrimidine with potassium hydroxide in ethanol for 0.666667 h;Heating;
Stage #2:methyl iodide in ethanol for 8 h;Heating;

Steps:

6-Amino-1, 3-dimethyl-1H-pyrimidine-2, 4-Dione (2)
To a heated ethanolic KOH solution (0.56 g, 10 mmol in 50 ml ethanol) compound 1 (1.27 g, 10 mmol) was added and heating was continuous for 40 min. The mixture was allowed to cool to room temperature, and methyl iodide (20 mmol) was added. The mixture was stirred under heating for 8 h and then allowed to cool to room temperature and finally poured into cold H2O (100 ml), The final product ppt. was filtered and washed with 100 ml H2O and crystallized from methanol to afford 2 as yellow crystals.

References:

Abu-Hashem, Ameen Ali;Hussein, Hoda Abdel Raouf [Letters in drug design and discovery,2015,vol. 12,# 6,p. 471 - 478]

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