7-Tosyl-7H-Pyrrolo[2,3-d]pyrimidine-5-boronic acid pinacol ester synthesis
- Product Name:7-Tosyl-7H-Pyrrolo[2,3-d]pyrimidine-5-boronic acid pinacol ester
- CAS Number:934178-97-9
- Molecular formula:C19H22BN3O4S
- Molecular Weight:399.27
![5-bromo-7-(p-toluenesulfonyl)-7H-pyrrolo[2,3-d]pyrimidine](/CAS/20200401/GIF/934178-96-8.gif)
934178-96-8
3 suppliers
inquiry
73183-34-3
591 suppliers
$6.00/5g
934178-97-9
47 suppliers
$225.00/250mg
Yield:934178-97-9 98%
Reaction Conditions:
with potassium acetate;(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride in 1,2-dimethoxyethane at 150; for 0.166667 h;microwave irradiation;
Steps:
1a; 1.iv
As shown in Figure 1-step iv, a mixture of compound 1004 (140 mg, 0.40 mmol), 4,4,5,5-tetramethyl-l,3,2-dioxaborolane dimer (121 mg, 0.477 mmol), PdCl2 dppf2 (16 mg, 0.02 mmol) and potassium acetate (117 mg, 1.19 mmol) in 2 mL of DME were microwaved at 1500C for 10 minutes. The reaction mixture was filtered through a short pad of silica gel with 30% EtOAc-70% hexanes as eluent to provide, after concentration to dryness, 158 mg (98%) of 5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)-7-tosyl-7H- pyrrolo[2,3-d ]pyrimidine, compound 1005: ESMS M+l = 317.07.
References:
WO2007/41130,2007,A2 Location in patent:Page/Page column 40-41; Sheet 1/9
![5-bromo-7H-pyrrolo[2,3-d]pyrimidine](/CAS/GIF/175791-49-8.gif)
175791-49-8
117 suppliers
$22.00/250mg
934178-97-9
47 suppliers
$225.00/250mg
![7H-Pyrrolo[2,3-d]pyrimidine](/CAS/GIF/271-70-5.gif)
271-70-5
193 suppliers
$8.00/100mg
934178-97-9
47 suppliers
$225.00/250mg
98-59-9
625 suppliers
$9.00/5g
934178-97-9
47 suppliers
$225.00/250mg