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ChemicalBook CAS DataBase List 1-(2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethyl)piperidine

1-(2-(4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethyl)piperidine synthesis

4synthesis methods
2008-75-5 Synthesis
1-(2-Chloroethyl)piperidine hydrochloride

2008-75-5
263 suppliers
$10.00/1g

269409-70-3 Synthesis
4-Hydroxyphenylboronic acid pinacol ester

269409-70-3
239 suppliers
$11.00/1g

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Yield:934586-49-9 80%

Reaction Conditions:

Stage #1: 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenolwith potassium carbonate in N,N-dimethyl-formamide at 0;
Stage #2: N-chloroethylpiperidine hydrochloridewith tetra-(n-butyl)ammonium iodide in N,N-dimethyl-formamide at 50;

References:

Malo-Forest, Bianca;Landelle, Grégory;Roy, Jessye-Ann;Lacroix, Jacques;Gaudreault, René C.;Paquin, Jean-Fran?ois [Bioorganic and Medicinal Chemistry Letters,2013,vol. 23,# 6,p. 1712 - 1715]

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