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Acetamide, 2-chloro-N-[(1S)-1-(hydroxymethyl)-2-phenylethyl]- synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: sodium tetrahydroborate; iodine / tetrahydrofuran / 0 - 80 °C
2: triethylamine / dichloromethane / 0 - 20 °C

References:

Campbell, Craig D.;Collett, Christopher J.;Thomson, Jennifer E.;Slawin, Alexandra M. Z.;Smith, Andrew D. [Organic and Biomolecular Chemistry,2011,vol. 9,# 11,p. 4205 - 4218]