Welcome to chemicalbook!
Chinese English Japanese Germany Korea
010-86108875
logo
Inquriy
Try our best to find the right business for you.
Messages
Do not miss inquiry messages Please log in to view all inquiry messages.
My chemicalbook

Welcome back!

Structured search
18162-48-6872-50-4Methylene ChloridenaphthaleneTHFTitanium Dioxide
942144-34-5

3-Oxazolidinecarboxylic acid, 2,2-diMethyl-4-[[(3R)-tetrahydro-2H-pyran-3-yl]Methyl]-, 1,1-diMethylethyl ester, (4S)- synthesis

6synthesis methods
3-Oxazolidinecarboxylic acid, 4-[(2R)-2-[[[(1,1-diMethylethyl)diMethylsilyl]oxy]Methyl]-5-[(Methylsulfonyl)oxy]pentyl]-2,2-diMethyl-, 1,1-diMethylethyl ester, (4S)-

942144-36-7
6 suppliers
inquiry

3-Oxazolidinecarboxylic acid, 2,2-diMethyl-4-[[(3R)-tetrahydro-2H-pyran-3-yl]Methyl]-, 1,1-diMethylethyl ester, (4S)-

942144-34-5
5 suppliers
inquiry

-

Yield:942144-34-5 54%

Reaction Conditions:

with N,N,N-tributylbutan-1-aminium fluoride;lithium hydroxide monohydrate in tetrahydrofuran;Reflux;

Steps:

1.7

Step 7. (S)-ter(-buty 2,2-dimethyl-4-(((Λ)-tetrahydro-2H-pyran-3-yl)methyl)oxazolidine-3- carboxylate; To a solution of (S)-tert-buty 4-(CK)-2-((tert-butyldimethylsilyloxy)methyl)-5-(methylsulfonyloxy)pentyl)-2,2-dimethyloxazolidine-3-carboxylate (37.7 g, 74.2 mmol) in THF (1000 mL) was added tetraethylammonium fluoride hydrate (41 g, 185.5 mmol) in portions. The reaction mixture was stirred under reflux overnight. The mixture was diluted with EtOAc (1000 mL), washed with water (300 mL) and brine (500 mL). The organic phase was dried over Na2SO4, filtered and concentrated in vacuo to give the crude product, which was purified by column chromatography to afford (S)-tert-buty 2,2-dimethyl-4-(((/?)-tetrahydro-2H-pyran-3- yl)methyl)oxazolidine-3-carboxylate (12.0 g, 54%).

References:

WO2009/154766,2009,A1 Location in patent:Page/Page column 36; 38

942144-12-9 Synthesis
CarbaMic acid, N-[(1S,3R)-1,3-bis(hydroxyMethyl)-5-hexen-1-yl]-, 1,1-diMethylethyl ester

942144-12-9
5 suppliers
inquiry

3-Oxazolidinecarboxylic acid, 2,2-diMethyl-4-[[(3R)-tetrahydro-2H-pyran-3-yl]Methyl]-, 1,1-diMethylethyl ester, (4S)-

942144-34-5
5 suppliers
inquiry

References
3-Oxazolidinecarboxylic acid, 4-[(2R)-2-(hydroxyMethyl)-4-penten-1-yl]-2,2-diMethyl-, 1,1-diMethylethyl ester, (4S)-

942144-13-0
6 suppliers
inquiry

3-Oxazolidinecarboxylic acid, 2,2-diMethyl-4-[[(3R)-tetrahydro-2H-pyran-3-yl]Methyl]-, 1,1-diMethylethyl ester, (4S)-

942144-34-5
5 suppliers
inquiry

References
1,2-Pyrrolidinedicarboxylic acid, 5-oxo-4-(2-propen-1-yl)-, 1-(1,1-diMethylethyl) 2-ethyl ester, (2S,4R)-

153080-81-0
8 suppliers
inquiry

3-Oxazolidinecarboxylic acid, 2,2-diMethyl-4-[[(3R)-tetrahydro-2H-pyran-3-yl]Methyl]-, 1,1-diMethylethyl ester, (4S)-

942144-34-5
5 suppliers
inquiry

References
3-Oxazolidinecarboxylic acid, 4-[(2R)-2-[[[(1,1-diMethylethyl)diMethylsilyl]oxy]Methyl]-4-penten-1-yl]-2,2-diMethyl-, 1,1-diMethylethyl ester, (4S)-

942144-14-1
7 suppliers
inquiry

3-Oxazolidinecarboxylic acid, 2,2-diMethyl-4-[[(3R)-tetrahydro-2H-pyran-3-yl]Methyl]-, 1,1-diMethylethyl ester, (4S)-

942144-34-5
5 suppliers
inquiry

References