CarbaMic acid, N-[(1S)-1-(azidoMethyl)-2-[(3R)-tetrahydro-2H-pyran-3-yl]ethyl]-N-Methyl-, 1,1-diMethylethyl ester synthesis
- Product Name:CarbaMic acid, N-[(1S)-1-(azidoMethyl)-2-[(3R)-tetrahydro-2H-pyran-3-yl]ethyl]-N-Methyl-, 1,1-diMethylethyl ester
- CAS Number:942145-26-8
- Molecular formula:C14H26N4O3
- Molecular Weight:298.39
Yield:942145-26-8 100%
Reaction Conditions:
Stage #1: tert-butyl (S)-1-azido-3-((R)-tetrahydro-2H-pyran-3-yl)propan-2-ylcarbamatewith lithium hexamethyldisilazane in tetrahydrofuran at -78; for 0.5 h;
Stage #2: methyl iodine in tetrahydrofuran at -78 - 0; for 12 h;
References:
Jia, Lanqi;Simpson, Robert D.;Yuan, Jing;Xu, Zhenrong;Zhao, Wei;Cacatian, Salvacion;Tice, Colin M.;Guo, Joan;Ishchenko, Alexey;Singh, Suresh B.;Wu, Zhongren;McKeever, Brian M.;Bukhtiyarov, Yuri;Johnson, Judith A.;Doe, Christopher P.;Harrison, Richard K.;McGeehan, Gerard M.;Dillard, Lawrence W.;Baldwin, John J.;Claremon, David A. [ACS Medicinal Chemistry Letters,2011,vol. 2,# 10,p. 747 - 751] Location in patent:supporting information; experimental part
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