3-ethynyl-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide synthesis
- Product Name:3-ethynyl-4-methyl-N-(4-((4-methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)phenyl)benzamide
- CAS Number:957147-18-1
- Molecular formula:C23H24F3N3O
- Molecular Weight:415.45
694499-26-8
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957147-18-1
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Yield:957147-18-1 89%
Reaction Conditions:
with triethylamine;N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate in N,N-dimethyl-formamide at 120; for 5 h;
Steps:
4
Step 4: 4-((4-Methylpiperazin-1-yl)methyl)-3-(trifluoromethyl)aniline (270mg, 1mmol), 3-ethynyl-4-methylbenzoic acid (160mg , 1mmol), HATU (400mg, 1.05mmol), triethylamine (200mg, 2mmol) in DMF (5mL) solution was stirred at room temperature for 15 hours, quenched with water, extracted with ethyl acetate, washed with saturated brine, the organic phase was dried and concentrated , Purified by column chromatography to obtain 370 mg of a white solid product with a yield of 89%.
References:
CN111484482,2020,A Location in patent:Paragraph 0124; 0125; 0129
![3-[2-trimethylsilylethynyl]-4-methyl-N-[4-((4-methylpiperazin-1-yl)methyl)-3-trifluoromethylphenyl]benzamide](/CAS/20200401/GIF/957147-17-0.gif)
957147-17-0
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957147-18-1
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694499-26-8
231 suppliers
$9.00/250mg
1416241-81-0
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957147-18-1
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90347-66-3
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957147-18-1
16 suppliers
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694499-26-8
231 suppliers
$9.00/250mg
957147-18-1
16 suppliers
inquiry