Acrivastine synthesis
- Product Name:Acrivastine
- CAS Number:87848-99-5
- Molecular formula:C22H24N2O2
- Molecular Weight:348.44
626-05-1
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87848-99-5
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Yield:-
Steps:
Multi-step reaction with 5 steps
1: 12.2 g / BuLi / hexane; diethyl ether / 3 h / -50 °C
2: 24.3 g / p-toluenesulfonic acid / toluene / 6 h / Heating
3: 2.5 g / BuLi / diethyl ether; hexane / 4 h / -50 °C
4: 1.) NaH, 2.) conc. HCl / 1.) DME, 2 h, 2.) ethanol, H2O, steam bath, 10 min
5: 1.) BuLi, 2.) NaOH / 1.) hexane, toluene, 75 deg C, 2 h, 2.) ethanol, steam bath, 10 min
References:
Findlay;Butz;Coker;et al. [Journal of Pharmaceutical Sciences,1984,vol. 73,# 10,p. 1339 - 1344]
87848-95-1
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87848-99-5
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![2-bromo-6-[2-(p-tolyl)-1,3-dioxolan-2-yl]pyridine](/CAS/GIF/87848-96-2.gif)
87848-96-2
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87849-03-4
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![6-[2-(p-tolyl)-1,3-dioxolan-2-yl]pyridine-2-carbaldehyde](/CAS/GIF/87848-97-3.gif)
87848-97-3
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87848-99-5
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