ADIPIC DIANILIDE synthesis
- Product Name:ADIPIC DIANILIDE
- CAS Number:4456-80-8
- Molecular formula:C18H20N2O2
- Molecular Weight:296.36
Yield:4456-80-8 98%
Reaction Conditions:
with dmap;1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride in chloroform at 20; for 10 h;Cooling with ice;Inert atmosphere;
Steps:
1
Adipic acid (manufactured by Wako Pure Chemical Co., Ltd. 15. 0g, 103mmol), aniline (Kishida Chemical Co., Ltd. 15. 9g, 171mmol) was weighed into a 3-mouth flask, and diluted to chloroform (180 ml), and ice-cooled under a nitrogen atmosphere. 1-(3-Dimethylaminopropyl)-3-Ethylcarbodiimide hydrochloride (Tokyo Kasei Co., Ltd. 39. 5g, 206mmol) and 4-di Methylaminopyridine (10mg) was added, and stirred for 10 hours at room temperature. Methanol (50ml) was added, and concentrated in an evaporator, the resulting residue methanol: Water = 1:1 (150ml) was washed with, dried the filtered resulting solids, compound as a white solid 2 (24. 8g, was obtained 98% yield.
References:
JP2018/58976,2018,A Location in patent:Paragraph 0211; 0214; 0215
124-04-9
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4456-80-8
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$12.00/1mg
2210-24-4
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4456-80-8
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$12.00/1mg