AKOS USSH-4110876 synthesis
- Product Name:AKOS USSH-4110876
- CAS Number:626226-54-8
- Molecular formula:C7H7N3O2S
- Molecular Weight:197.21
420-04-2
377 suppliers
$15.00/25g
638-07-3
502 suppliers
$5.00/5G
556-61-6
187 suppliers
$27.50/5g
626226-54-8
9 suppliers
$23.00/1g
Yield:626226-54-8 72%
Reaction Conditions:
Stage #1: CYANAMID;methyl thioisocyanatewith potassium hydroxide in ethanol at 20; for 1 h;
Stage #2: ethyl (2-chloroaceto)acetatewith potassium hydroxide in ethanol; for 0.5 h;Reflux;
Stage #3: with hydrogenchloride in ethanol;water at 20; pH=7;regioselective reaction;
References:
Shestopalov, Anatoliy M.;Rodinovskaya, Liudmila A.;Shestopalov, Alexander A. [Tetrahedron,2010,vol. 66,# 46,p. 8945 - 8948] Location in patent:supporting information; experimental part