2-Oxotetrahydrofuran-3-yl methacrylate synthesis
- Product Name:2-Oxotetrahydrofuran-3-yl methacrylate
- CAS Number:195000-66-9
- Molecular formula:C8H10O4
- Molecular Weight:170.16
4245-37-8
83 suppliers
$28.25/5g
19444-84-9
136 suppliers
$13.00/250mg
195000-66-9
126 suppliers
$129.00/5G
Yield:195000-66-9 93.72%
Reaction Conditions:
with p-benzoquinone in hexane at -18; pH=7-8; for 7 h;Green chemistry;
Steps:
8 Example 8: Synthesis of 2-carbonyl-tetrahydrofuran-3-hydroxy-methacrylate
Add 4073ml of n-hexane in the 5L four-necked flask equipped with stirring paddle, condenser and thermometer, turn on stirring, add 78.10g of 2-carbonyl-tetrahydrofuran-3-ol to the system, slowly add 0.03g of polymerization inhibitor p-benzoquinone to the reaction system, add 107.2g basic ion exchange resin, adjust pH=7-8, cool down to -18°C, slowly add 107.2g vinyl methacrylate dropwise to the reaction system, keep the reaction for 7h, monitor the reaction progress, and take samples for detection After the reaction was completed, 1000 ml of water was added to the reaction system, and the mixture was stirred for extraction and phase separation. The organic phase was dried, concentrated under reduced pressure and evaporated to dryness to obtain 122 g of 2-carbonyl-tetrahydrofuran-3-hydroxy-methacrylate product with a yield of 93.72%. Figure 8 shows the gas chromatogram of the 2-carbonyl-tetrahydrofuran-3-hydroxy-methacrylate synthesized in this example.
References:
CN114560768,2022,A Location in patent:Paragraph 0085-0088; 0099
5061-21-2
312 suppliers
$25.00/5G
79-41-4
529 suppliers
$14.00/5g
195000-66-9
126 suppliers
$129.00/5G
79-41-4
529 suppliers
$14.00/5g
195000-66-9
126 suppliers
$129.00/5G
5061-21-2
312 suppliers
$25.00/5G
79-41-4
529 suppliers
$14.00/5g
108-10-1
895 suppliers
$12.00/25ml
195000-66-9
126 suppliers
$129.00/5G